Mr. Wang, came to Beijing Ditan Hospital for liver cancer. After CT examination, it was found that the hepatocellular carcinoma was located in the right lobe of the liver with a maximum diameter of 9.5 cm, and the portal vein cancer thrombus had extended into the main trunk of the portal vein, which was an advanced stage of liver cancer. After two catheter interventions of embolization, the tumor vessel was interrupted, and then through the subxiphoid approach, the cancer thrombus of the right branch of the portal vein was absolved from the left branch of the portal vein by overlapping stent, which prevented the cancer thrombus from spreading to the main trunk of the portal vein, and at the same time ensured the normal portal blood supply to the left half of the liver. The tumor decreased to 3.9ug/ml, and no metastases were seen in the liver. There are about 320,000 new hepatocellular carcinomas in China every year, 80% of which are in the middle and late stages and have lost the chance of surgery, and many patients have portal vein metastasis and portal vein cancer thrombosis. Based on the theory of “no blood supply, no tumor”, our department has achieved satisfactory clinical efficacy by embolizing the arterial bed of tumor, using overlapping stent to open the portal vein tumor embolus, and performing large-scale radiofrequency ablation treatment under the ischemic state of tumor. The application of the overlapping stent can prevent the cancer embolus from continuing to spread to the main trunk of the portal vein and also prevent the metastasis of the cancer embolus to the contralateral liver, while also ensuring and maintaining the blood supply into the liver of the remaining liver. After this method of treatment, the tumor showed ischemic necrosis and coagulative necrosis, the clinical symptoms caused by the cancer embolus were relieved or disappeared, and the liver function was protected. Now we will share the treatment experience of this patient with you, hoping to relieve the pain of patients with portal vein cancer embolism. The first step of surgery: placement of portal vein stent; the second step: ablation of intrahepatic tumor.