Experts believe that 70%-80% of cancers are caused by poor lifestyle and environment, the most important factors are heredity, environmental pollution, unreasonable diet, smoking, alcoholism, obesity, insufficient exercise and excessive psychological stress. CDC experts point out that if cancer can be detected, diagnosed and treated early, 1/3 can be prevented, 1/3 can be cured, and 1/3 can prolong life through active treatment and care. Therefore, to prevent and control tumors, in addition to primary prevention, early detection, early diagnosis and early treatment are the keys to improve the cure rate of tumors. And to achieve the goal of secondary prevention, it is most important for all people to participate and raise the awareness of cancer prevention among the population through propaganda and education, so that the public can understand the early symptoms of cancer, master self-examination methods and take the initiative to receive screening and clinical examination. In clinical practice, we often come across many liver cancer patients who always have many questions about their disease during treatment. The most frequently asked questions are: Why is liver cancer mostly in the middle and late stages when it is detected? Is liver cancer curable? Should liver cancer be treated by surgery, interventional therapy, drug therapy or liver transplantation? These are the three questions that most liver cancer patients are concerned about. Question 1: Why liver cancer has no symptoms in the early stage but is mostly in the middle and late stage when it is detected? Experts explain: The liver is an organ with strong compensatory capacity, and the lumps in early stage liver cancer are usually around 3-5cm, some are even smaller. Due to the strong compensatory ability of liver, liver function can still maintain normal performance, therefore, it does not show symptoms. Early stage liver cancer is usually found during physical examination. It is only when the mass has grown larger and more serious liver function impairment has occurred that clinical symptoms, such as: jaundice, ascites, and pain in the liver area, will be manifested. Therefore, we emphasize the need for screening in high-risk groups. By high-risk group, we mean: people aged 40 years or older; people with a history of hepatitis or or carriers of hepatitis viruses, especially hepatitis B and C viruses; people with unexplained liver pain, wasting, and progressive hepatomegaly; long-term alcohol consumption; and people with abnormal quantification of alpha-fetoprotein (AFP). It is best to have quantitative AFP (alpha-fetoprotein) test once in three months to six months for high-risk group. If it shows alpha-fetoprotein (+), persistently elevated alpha-fetoprotein quantification, or alpha-fetoprotein >400 ug/ml for more than 1 month, it needs to be noticed. If necessary, the following tests are also available — A. Blood enzymatic tests: such as elevated r-glutamyl transpeptidase, alkaline phosphatase and lactate dehydrogenase. B.B ultrasound: the diagnosis rate is 90%, and can detect tumor of 1 cm in diameter. C, MRI (magnetic resonance imaging): it can show tumors of 0.5 cm in size. D. Abdominal artery or hepatic artery angiography: the diagnostic rate can reach 90%. E.TEP (positron CT scan): it can examine the masses that cannot be shown by other imaging means. F. Dissection or transabdominal laparoscopic exploration: for patients who are still undiagnosed and highly suspicious, dissection or laparoscopic exploration can be performed when necessary. Generally speaking, ultrasound and quantitative alpha-fetoprotein test at least once every 6 months are simple and effective methods for early diagnosis of hepatocellular carcinoma. Question 2: Can liver cancer be cured? Chen Yazin: For a long time, liver cancer has been called the “king of cancer” and people are afraid of it. In fact, the belief that liver cancer is not curable is not correct, because with the development in recent decades, the overall effect of liver cancer treatment has increased by 30%. In the mid-1980s, our hospital performed the second-stage resection of a huge liver cancer patient, and the patient has survived for 18 years. Therefore, liver cancer is not an incurable disease, the key is early detection and early treatment. Question 3: There are surgical treatment, interventional treatment, chemotherapy, targeted therapy, biological treatment and liver transplantation for liver cancer treatment, which one is better? Chen Yajin: At present, the overall pattern of liver cancer is still a comprehensive treatment mainly based on surgery, which is the preferred treatment mode recognized both at home and abroad, and some patients can achieve the effect of radical cure through surgery. Therefore, patients with hepatocellular carcinoma who can be surgically resected should be resected as much as possible, and then supplemented with interventional chemotherapy, targeted therapy, biological therapy and other comprehensive treatments. Those who cannot be removed temporarily can be treated by interventional, radiological and local methods, and then removed after the tumor shrinks, and recurrent tumors can be removed again. For early stage liver cancer, liver transplantation can also be performed, while the effect of liver transplantation for middle and late stage liver cancer is relatively poor. For unresectable hepatocellular carcinoma, interventional therapy is preferred, and then combined with local therapy, targeted therapy and biological therapy to prolong the life span. Although the tumor cannot be removed or relapsed and metastasized, various measures to control the tumor growth can achieve the efficacy of coexistence with tumor, improve the quality of survival and increase the overall survival rate. In conclusion, the positive and optimistic spirit of “not fearing, not giving up and not abandoning”, combined with the treatment policy of “early, active, comprehensive and specific” is the magic weapon to overcome liver cancer.