1, physical examination: should be carried out at least once a year, for high-risk groups should be more frequent. It is necessary to observe vascular pulsation, hair growth, skin temperature and capillary refill, foot and heel deformity and tissue destruction, location and size of ulcers, edema or inflammatory manifestations. The stability of the joints and the strength of the muscles should also be checked. 2.Neurological examination: the motor and sensory functions of the nerves can be examined by electromyography. 3. Vascular examination: arterial Doppler ultrasound. Ankle-brachial index measurement: below 0.9 means there is a certain degree of limb blood supply deficiency; below 0.5 predicts serious limb ischemia. Vascular enhancement CT can better reflect the lesions of blood vessels. Angiography is the “gold standard” of diagnosis. 4.Laboratory tests: blood glucose, glycated hemoglobin, biochemical tests and other indicators, the changes of these indicators indicate the patient’s compliance and optimal healing. Imaging: Plain X-rays are used to evaluate osteolysis/bone destruction, dislocation, subluxation, and bony structural changes in the foot and ankle, CT is used to evaluate details of cortical bone and soft tissue disorders such as abscesses, and MRI is sensitive to soft tissue and bone tissue changes from various causes such as stress fractures, abscesses, osteomyelitis, or neuropathic arthropathy.