Uterine adenocarcinoma is a malignant tumor of the reproductive tract that poses a serious threat to women’s health. The main symptom of uterine adenocarcinoma is vaginal bleeding, which is usually small in amount. In the late stage of the disease, there will be abnormal pain in the lower abdomen and lumbosacral region, which may radiate to the lower limbs and feet, and in the late stage of the disease, there will be wasting, anemia, fever and general exhaustion. The early symptoms of uterine adenocarcinoma are not obvious, and are only discovered by chance during physical examination or by pathological indication after scraping for irregular vaginal bleeding. Once symptoms appear, many of them are already in the middle or advanced stage. The treatment of uterine adenocarcinoma can be divided into surgery, radiotherapy, chemotherapy and drug adjuvant therapy, etc. We should pay attention to physical examination, active prevention and early detection, which can increase the survival rate of patients and improve the quality of life.