Children with purpura nephritis are in a serious condition. The causes of purpura are allergic causes and thrombocytopenia. These conditions can cause autoimmune reactions, the emergence of immune antibodies, affecting the kidney, resulting in antibody complexes, deposited in the glomerular basement membrane, affecting the filtration function of the kidney, causing purpura nephritis, affecting the kidney function, so the condition is more serious. More serious cases may cause renal failure, need to apply glucocorticoids, anti-immune, reduce the immune damage, and identify the cause of the disease for the cause, the application of drug therapy.