Hemangioma of the S6 segment of the liver is a direct diagnosis of an intrahepatic lesion; the corresponding lesion is benign, and generally small lesions do not require much intervention, and specific cases need to be handled under the guidance of the clinician. The S6 segment of the liver refers to the lower right posterior lobe of the liver, and if a blood sinusoidal lesion is detected in it through imaging, it will be diagnosed as S6 segment hemangioma; strictly speaking, the lesion is a tumor-like lesion, which belongs to a kind of vascular malformation; most of the small hemangiomas do not have clinical symptoms, and belong to the discovery of physical examination; the larger hemangiomas have the compression to the surrounding tissues or have the risk of rupture, and need to be interventional therapy. Once obvious abdominal pain occurs in hemangioma of S6 segment of liver, it is necessary to consult a doctor in time for observation and standardized treatment under the guidance of clinicians.