We all know that mental illness is a chronic and prolonged disease, characterized by one exacerbation per episode. The most common treatment for mental illness is medication, sometimes combined with psychotherapy and physical therapy. However, some patients still do not see any effect after these treatments, and even deteriorate. Many patients’ families are deeply disappointed, and some simply give up treatment. In most cases, psychotherapy and physiotherapy play an auxiliary role. For hallucinatory delusions, psychotherapy and physical therapy are almost ineffective. For refractory mental illnesses, what else is available when the above treatments are ineffective? That is neuromodulation, including modern psychosurgery radiofrequency ablation and deep brain electrical stimulation (DBS). Radiofrequency ablation therapy is most suitable for treating various refractory psychiatric disorders, including schizophrenia, affective psychosis, obsessive-compulsive disorder, anxiety disorder, tic disorder, drug dependence, and epilepsy-induced psychiatric disorders, while DBS is most suitable for treating Parkinson’s disease. Ms. Shen, 38 years old, went to France to study 20 years ago and got a green card. But unfortunately, she developed a mental disorder, which has been 8 years, babbling, sensitive and suspicious, thinking that someone was trying to harm her, putting poison on her, disowning her parents, often scolding them, having recurrent episodes, and her work life was not normal, and repeated hospitalization up to a dozen times still did not work. In the process of seeking medical treatment, I learned by chance that a friend’s child had undergone surgical ablation treatment at Eastern Hospital and her parents had personally observed the effect of the treatment, so I chose the surgical RF ablation treatment. Why can radiofrequency ablation treat refractory mental illness? This is because the procedure can directly ablate the neural circuit that causes mental illness, thus blocking the neuropathic impulses and providing a sustained treatment effect. Medication usually takes 2 weeks to 4 weeks to take effect, and surgical radiofrequency ablation treatment is effective upon awakening. Temper tantrums disappear and apologize to parents saying sorry; patients who do not speak and refuse to eat talk to their families and initiate food after surgery; even those who have not read books for more than a decade ask to read books, etc. There are various reasons why many people do not understand this treatment method, mainly because medical education and medical publication introduce insufficient propaganda, or the view is still stuck in the situation of 50-60 years ago abroad. With the progress of science and technology, especially the development of neuroimaging, neurobiology, molecular science, microelectronics, etc., people’s understanding of mental illness is becoming more and more profound, and the localization techniques are becoming more and more accurate. Now we are using digital localization technology, which is the most advanced technology abroad, and it is a visualized, real-time, individualized and precisely located minimally invasive treatment, so the efficacy has improved and the adverse effects have been significantly reduced. We have proven through the follow-up of 401 cases for an average of 3 years that the efficiency is 95%, with no significant impact on cognitive function and normal intelligence and limb movement. This treatment can be considered as the last resort in the treatment of refractory psychiatric disorders after ineffective pharmacological treatment.