If the pain is in the exact area where there is a breast nodule, the pain may be related to the breast nodule. Small nodules generally do not put particularly much pressure on the interstitial glands of the breast and, therefore, may not have any symptoms. When a nodule grows to a certain size, it may compress the breast gland, and with many sensory nerves running through the gland, it may experience pressure and pulling, and pain may be felt. Most people find that the side of the gland that seems to have a small nodule is a little painful, often not necessarily related to the nodule itself, but possibly because the gland around the nodule has hyperplasia, which is a hardening of the interstitial mass of the gland, which can compress the nerves running through the gland and make it feel a little painful. Therefore, most of this pain is not related to small nodules, unless the nodule grows very large.