The goal of diabetic foot prevention and treatment is prevention-oriented, early diagnosis and early treatment, which not only can significantly improve the quality of life of diabetic patients, but also can greatly reduce the related medical expenses, with important social and economic benefits. Blood glucose control is the foundation: strict control of blood glucose, active correction of ketoacidosis, hypoproteinemia, cardiac, cerebral and renal complications and various adverse factors that affect gangrene healing. Support symptomatic treatment: including restricting activities, reducing weight load, elevating the affected limbs to facilitate blood return to the lower limbs, and reducing edema. Improve patient education, proper foot care, and prevention of injury from external sources. Prevention and treatment of infection is the key: Among the pathogenic bacteria of diabetic foot infections, Staphylococcus aureus is common, followed by Streptococcus, Enterococcus, Enterobacter and anaerobic bacteria, etc. Long-term application of iodophor and other drug changes often have Pseudomonas aeruginosa and fungal infections. The principle of using antibiotics in the treatment of diabetic foot infections is: broad-spectrum antibiotics can be used for a short time in the case of unknown pathogenic bacteria. After the pathogenic bacteria are identified by drug sensitivity test, treatment with sensitive antibiotics should be used. The duration of treatment can be decided according to the results of clinical signs, blood sedimentation and peripheral blood routine, microbiological examination, etc. The duration of anti-infective treatment is about 2 weeks for infections not involving bone, and several months for those with osteomyelitis. Long-term application of antibiotics may cause secondary infections and dysbiosis of the body flora. The application of herbal medicines to clear heat and detoxify the body and to reduce dampness and swelling can significantly reduce the production of drug-resistant bacteria, and most patients can be treated with herbal medicines alone. Removal of necrosis is important: local debridement, removal of necrotic tissue, placement of drainage, and routine disinfection and dressing changes. If the diabetic foot gangrene is infected gangrene, drug changes should be based on thorough debridement. Local redness, swelling, and pulsating sensation can be promptly incised to fully expose the degenerated tendons and gradually remove the deep inactivated tendons and necrotic tissue from the rotting tendons and penetrating ulcers. The wounded surface should be kept clean and breathable, and wet dressing with triple yellow lotion gauze should be applied. After the sinus tract is cleared of rotten tendons, medicated threads such as Jiuyi Dan and Baidan can be inserted to drain and pull out the poison, dispel the rot and create muscle. In addition, pay attention to local cleanliness and disinfection, the use of neoclean tincture, hydrogen peroxide solution, iodine volts, etc., a wide range of disinfection of the affected foot, especially between the toe crevices and heel chaps, in order to kill the fungus. Antifungal and anti-anaerobic herbal cleansing and topical application, such as Inoceramus, bitter ginseng, alum, neem, etc. If the diabetic foot ulcer is mainly ischemic, it is sufficient to use topical application of decay-eliminating and muscle-generating drugs according to different conditions. To improve circulation and promote healing: 1. For those whose vascular lesions are not very serious or without surgical indications, they can be treated conservatively by internal medicine, using blood-vitalizing and blood-stasis-transforming herbs such as lanugenin, thromboplasmin, Chuanxiong, Danshen and other injections; vasodilating drugs such as prostaglandin, butalbital, 654-2, poppy bases, etc. 2.For those with serious vascular lesions, on the basis of conservative treatment, revascularization should be performed. It can make part of the large vascular lesions caused by gangrene of the extremity from amputation surgery. Commonly used methods include vascular bypass surgery, endarterectomy, tipped large omentum graft, percutaneous vascular balloon dilatation and angioplasty, endovascular stenting, etc. 3, for gangrene patients in serious life-threatening infection, to decisively perform amputation. 4, hyperbaric oxygen therapy: hyperbaric oxygen can improve the vascularization of new tissue and promote wound healing. Hyperbaric oxygen therapy is contraindicated for serious infections of non-anaerobic bacteria, especially those with combined pulmonary infections. Nerve nutrition to prevent recurrence: Change the abnormal stress of the foot to take reasonable treatment, 90% of neuropathic ulcers can be healed by conservative treatment. The key to treatment is to reduce the pressure caused by the primary disease, to find out whether the patient has altered pressure distribution and its location by means of a foot manometer, and then to use special orthopedic shoes or orthoses to change the pressure in the patient’s foot. No domestic studies have been reported in this area. To improve nerve function, B vitamins, nerve growth factor and other drugs that promote nucleic acid and protein synthesis in nerve cells, axonal regeneration and myelin formation are available.