During the perimenopause, due to the decrease of estrogen level, vasodilatory disorders and psychoneurological symptoms may occur. Under the regulation and compensation of the autonomic nervous system of the body, most women have no obvious symptoms, while some women may experience hot flashes, sweating, insomnia, depression or irritability, which is called menopausal syndrome. Recent symptoms include menstrual disorders, irregular cycles, prolonged periods, changes in menstrual volume, hot flashes and night sweats, and other vasodilatory symptoms, as well as palpitations, dizziness, headache, insomnia, tinnitus, lack of concentration, memory loss, and mood swings. In the long term, vaginal dryness, difficulty in sexual intercourse, recurrent vaginal infections, difficulty in urination, osteoporosis, arteriosclerosis and other cardiovascular pathologies may be present. Treatment can be done by psychological guidance, popularizing related knowledge, making women face naturally with an optimistic attitude, encouraging the establishment of a healthy lifestyle, insisting on physical exercise, a healthy diet, increasing sun exposure time, consuming sufficient protein and calcium-rich food to prevent osteoporosis, and in addition using estrogen supplementation therapy, which can effectively relieve menopause-related symptoms and thus improve the quality of life.