The perimenopausal period includes the period from the appearance of endocrine, biological and clinical features associated with menopause until 1 year after the last menstrual period. The early or late age of menopause is related to ovarian reserve function and consumption, nutrition, regional environment, and the presence of ovarian surgery for smoking, etc. The average age of menopause for urban women in China is 49.3 years and 47.5 years in rural areas. In addition to some menstrual and physical changes, there are more specific symptoms of vasoconstriction, including hot flushes, night sweats, body weakness, palpitations, and vertigo. About 75% of perimenopausal women feel hot flashes, but this drops to 60% after menopause. About 90% of patients with surgically induced menopause complain of hot flashes in the first year. Hot flashes may usually last 4-10 minutes or may be as short as a few seconds. However, at short intervals, the patient may feel very hot at one time and then very hot at another, with night sweats, etc. Hot flashes can also cause insomnia, which can lead to a depressive state in the long run. This is a domino theory. The Harvard study proved that perimenopausal women with hot flashes have about 3.5 times higher risk of menopausal depression compared to perimenopausal women without hot flashes. 10-20% of women feel that hot flashes are unbearable, resulting in severe anxiety and depression.