Hyperuricemia is a metabolism-related disorder that is becoming more prevalent as the standard of living rises. 1. For hyperuricemia, the diagnostic criteria are different for men and women. The blood uric acid level for men is <420 UMOL/L and for women is <360, but the standard for postmenopausal women is the same as that for men. 2. There are two main types of drugs for the treatment of high uric acid, one is to inhibit the production of uric acid, represented by allopurinol; the second is to promote the excretion of uric acid, such as benzbromarone. 3. As with hyperglycemia, despite the emphasis on low purine diet, dietary control often does not reduce blood uric acid to a satisfactory level, so drug control is needed. 4. Allopurinol is inexpensive, but what must be known is that it can lead to severe allergic reactions, exfoliative dermatitis, and is a life-threatening and serious condition. Therefore, many countries and regions in Asia require testing of the patient's HLA-B5801 gene, and a positive result means a possible allergy to allopurinol and its use is strictly prohibited. 5.Benzene bromarone can cause higher liver damage in Europe and America, on the contrary, allergy to allopurinol is rare. Therefore, allopurinol and other uric acid production inhibitors are recommended to reduce uric acid in the United States, and the use of benzbromarone is not advocated, but it is safe among Asians. 6. When using benzbromarone, drink a lot of water and urinate in order to avoid the formation or aggravation of uric acid stones due to excessive uric acid elimination.