The need or choice of antimicrobial agent for kidney stones is determined by the results of the urine culture. If a urine culture is performed for a kidney stone and the culture is negative and there is no bacterial growth, no antimicrobial agent is required for treatment. However, if the culture shows pathogenic bacteria, it is necessary to select antimicrobial treatment according to the drug sensitivity test of the cultured pathogenic bacteria. In principle, the antimicrobial agents of quinolones or cephalosporins are usually chosen, and the commonly used drugs include levofloxacin hydrochloride, ciprofloxacin or moxifloxacin, etc. Cephalosporins are often chosen as cephalosporin II antimicrobials, such as cefuroxime sodium for injection or cefoxitin sodium for injection. Cefoxitin sodium for injection and other drugs to carry out anti-infection use. However, it should be noted that antimicrobial agents do not dissolve stones and do not promote stone discharge, but only control stone co-infection and make the infection heal, so that in the process of treating stones, there will be no spread of infection, no urogenital sepsis or rapid increase in body temperature, etc.