How long it takes to turn negative for HPV52 varies from person to person. Most patients have a transient HPV infection and only a small percentage of patients may have a persistent infection. HPV52 infection is a high-risk type of human papillomavirus and carries a risk of cervical intraepithelial lesions and cervical cancer. If HPV52+ patients are advised to undergo colposcopic biopsy to determine if cervical intraepithelial neoplasia has occurred. If there is no cervical intraepithelial neoplasia and only HPV infection, the rate of self-reversal is high for younger patients with a more resistant organism; if it remains positive for 1 year, it is a persistent state of infection. For older patients or those with a family history of high risk, they can be treated with interferon, which is usually reviewed after 3 months of use and helps to turn negative, and only a few patients may be in a persistent state of infection. Therefore, colposcopy is recommended for patients with HPV52 infection to determine if lesions have developed. In the absence of lesions, periodic rechecking is required.