Why breast cancer patients are more prone to osteoporosis? With back pain, lower limb movement disorders and even fractures, breast cancer patients have to face the pain caused by bone loss in their bodies while fighting against tumors. Endocrine therapy for breast cancer, especially the emergence of aromatase inhibitors, has caused many women to develop osteoporosis prematurely. What is more frightening is that this danger often occurs quietly and once it happens, it causes endless troubles to patients. As we all know, the reason why endocrine therapy can occupy a very high position in breast cancer treatment is that breast cancer is an estrogen-dependent tumor. Endocrine therapy is to inhibit the growth of tumor cells by suppressing the level of estrogen. But unfortunately, the presence of estrogen is almost essential for the female skeleton. One study showed that postmenopausal breast cancer patients who used aromatase inhibitors had 1.5 times the risk of fracture than those who did not. However, the role of aromatase inhibitors should not be dismissed for this reason. On the contrary, it is precisely because of the use of this treatment that the survival of breast cancer patients is significantly prolonged and that the chronic disease of osteoporosis has the opportunity to manifest itself. To abandon endocrine therapy in order to reduce the risk of osteoporosis is definitely an act of missing out on a small amount. ”It is perfectly possible to take timely measures to deal with bone loss while treating breast cancer. First of all, patients should take precautionary measures by taking calcium and vitamin D supplements at the right time and exercising reasonably; secondly, they should know themselves and their enemy by taking bone density measurements, so that they can make a general estimation of the rate of bone loss caused by breast cancer treatment. Lastly, we should “prescribe the right medicine” and use different levels of anti-osteoporosis treatment at different stages, such as calcitonin, active vitamin D or bisphosphonates to stop bone loss if necessary. In addition, bisphosphonates are effective in preventing bone metastases in breast cancer patients, which can kill two birds with one stone.