1. Peripheral neuropathy (mainly sensory abnormalities): Myeloma disease itself and certain drug treatments may cause peripheral neuropathy. Patients with pre-existing symptoms (numbness, pain or burning sensation in the feet or hands) and other signs of peripheral neuropathy may experience an increase in these symptoms during drug therapy. Patients must be monitored for signs of neuropathy such as burning, sensory sensitivity, dullness, abnormal sensation, discomfort, or neuralgia. Patients with new or worsening peripheral neuropathy need to consult your primary care physician immediately and may need to change the dose and dosing schedule of the drug. Peripheral neuropathy caused by long-term thalidomide use is usually irreversible and difficult to recover from. Most patients with peripheral neuropathy caused by Vanco can gradually recover or improve their discomfort after the dose is reduced or discontinued, with a median recovery time of 110 days. 2. Nausea, vomiting The use of drug therapy may cause nausea, vomiting and other uncomfortable symptoms. You can discuss with your primary care physician the need for anti-emetic medication to prevent this. You can also use light, sour drinks in your diet and avoid foods that are too sweet or greasy. In particular, avoid eating for 2-3 hours before receiving high dose chemotherapy to prevent vomiting. Also pay attention to the balance of water and electrolytes to avoid dehydration symptoms. 3.Diarrhea Symptoms such as diarrhea may occur when receiving chemotherapy, and a hygienic diet is the key to prevention. You should also avoid eating foods with high fat content and fried foods. It is also important to pay attention to the balance of water and electrolytes. A controlled diet and small amounts of food are also good ways to prevent diarrhea. If diarrhea occurs, you should seek immediate help from your doctor. 4. Thrombocytopenia Patients may experience transient thrombocytopenia during Vanco treatment, which may induce bleeding in severe cases. Usually the platelets can gradually recover during the subsequent ten-day rest period (i.e. before the next course of treatment begins). Patients should prevent bleeding by applying local pressure to the injection site for 5-10 minutes after blood sampling or injection to prevent bleeding, and inform the nurse if bleeding cannot be stopped; do not brush your teeth with a hard toothbrush, but use mouthwash given by your physician; avoid trauma as much as possible; monitor blood count regularly, and if necessary, perform platelet transfusion under the guidance of your physician.