Primary mesenteric lymph node carcinoma is uncommon, and the one with a greater incidence is mesenteric non-Hodgkin’s lymphoma. However, as a relay station of lymphatic flow, almost all malignant tumors in the abdominal cavity can be metastasized through it, and mesenteric lymph nodes are susceptible to involvement and metastatic cancer in mesenteric lymph nodes. 1. mesenteric non-Hodgkin’s lymphoma: the clinical symptoms of this disease are usually loss of appetite, abdominal distension and abdominal masses, etc. The symptoms lack specificity and usually require CT and other imaging examinations to assist in diagnosis. The disease is usually diagnosed by CT and other imaging examinations, and can be seen as enlargement and necrosis of multiple mesenteric lymph nodes and thickening of the adjacent intestinal wall. 2.metastatic cancer of mesenteric lymph nodes: metastatic cancer of mesenteric lymph nodes commonly occurs in the middle and late stages of gastrointestinal malignant tumors such as esophageal cancer, gastric cancer, rectal cancer, etc. When these primary tumors metastasize, the infiltrated tumor cells pass through the lymphatic vessel wall, shed and then transfer to the mesenteric lymph nodes along the lymphatic network with the lymphatic fluid drainage step by step. The clinical manifestations of metastatic cancer in mesenteric lymph nodes can be observed by imaging means, such as ultrasound and CT, which can show the enlargement and necrosis of local lymph nodes in mesentery. If metastatic cancer of mesenteric lymph nodes occurs, surgery is usually required to remove the primary tumor lesion and, according to the metastasis, to cleanse all the lymph nodes where cancer occurs, and to carry out adjuvant treatments such as radiotherapy and chemotherapy to prevent further spread of tumor cells. Whether mesenteric lymph nodes are cancerous or not needs to be diagnosed through professional techniques. If such a condition is suspected, it is recommended to go to hospital for examination and treatment in time to avoid further aggravation of the condition and serious consequences.