Gout is coming, but also brought atrial fibrillation! ”The heart is a delicate, sensitive organ that is particularly susceptible to “outside” influences, and the heart can feel the slightest discomfort before the rest of the body. Source: Atrial fibrillation (AF) is one of the most common clinical arrhythmias that can lead to stroke and other thromboembolic complications, induce and exacerbate heart failure, and is an important cause of disability and death. Studies have confirmed that neurohormonal activation, upregulation of oxidative stress, and immune activation may contribute to the development of AF, but the etiology of AF is still unclear. The Framinham study showed a 4- to 5-fold increased risk of stroke in patients with AF. Interestingly, certain risk factors for stroke and AF are also common comorbidities in gout patients. Gout, a metabolic arthritis caused by the accumulation of uric acid as a result of impaired purine metabolism, afflicts 1 in 4 people in the UK. Serum uric acid (SUA) has become an important plasma marker for a variety of cardiovascular diseases including coronary heart disease and heart failure, and as a terminal metabolite of purines in the body catalyzed by xanthine oxidase, it is not only an endogenous signal for cell damage activation of immune response, but also closely related to the pro-inflammatory state of the body. The process requires a two-step reaction: the conversion of hypoxanthine to xanthine and xanthine to uric acid, both of which are catalyzed by xanthine oxidase. Thus, an increase in blood uric acid level reflects an increase in xanthine oxidase activity. Recent studies have shown that xanthine oxidase activation can lead to excessive production of reactive oxygen species (ROS), which can cause structural remodeling of the atria and promote the development of AF. Although some evidence suggests that hyperuricemia is a risk factor for AF, the link between gout and AF has not been fully established. So, is there a potential link between SUA and AF? A recent study suggests that hyperuricemia is associated with left atrial hypertrophy. There is growing evidence that hyperuricemia is an independent risk factor for the development of AF and is associated with thromboembolism in AF patients. A study of 45,378 patients from the United Kingdom found that patients with gout were at significantly increased risk of developing AF. Patients who were first diagnosed with gout and age- and sex-matched patients were selected as controls, and a significantly increased risk of AF was found in the gout group compared with the control group (7.42% vs. 2.98%, p<0.001). < p=""> The Greek scholar Deftereos S found that colchicine, which has specific effects on acute gouty arthritis, prevented recurrence of atrial fibrillation after pulmonary vein isolation (PVI) in a safe and effective manner. At the same time, Deftereos S found a recurrence rate of 31.1% (32/103 cases) in the colchicine group versus 49.5% (51/103 cases) in the placebo group after a single radiofrequency ablation during a two-year follow-up period, with a reduced relative risk ratio of 37%. This indicates that colchicine can effectively reduce the recurrence rate of atrial fibrillation after a single radiofrequency ablation, and can also effectively improve the quality of life of patients. Therefore, patients diagnosed with gout, especially those who are older or have risk factors for atrial fibrillation, should pay attention to the presence of palpitations, vertigo, . chest discomfort, shortness of breath, and regular electrocardiograms to assess the possibility of atrial fibrillation.