A more innovative diagnosis and treatment concept
More profound diagnosis level
More comprehensive treatment plan
1.Is it a tumor and does it need deep surgery?
There are some brain diseases that are easily misdiagnosed by simple clinical manifestations and imaging examinations, and the craniotomy based on misdiagnosis is more than worth the loss. We use the unique guided biopsy function of magnetic navigation system to achieve pathological detection of tissue in the focal area with an error of less than 1mm, realizing minimally invasive confirmation of diagnosis and avoiding numerous fearless traumas.
2.Glioma has no boundary, how to distinguish normal brain tissue from tumor tissue?
Most gliomas are malignant tumors and there is no clear boundary between them and normal brain tissues, but tumor tissues are richer in blood vessels than normal brain tissues, and there are also obvious differences between tumor cells and normal cells in terms of metabolism and neuroelectrical activities. These differences can be used to determine the interface of the tumor and to achieve the maximum extent of tumor resection and the maximum preservation of neurological function.
(1) Preoperative MRI-enhanced navigation sequence scan. Based on the differences in MRI imaging between normal brain tissue and glioma tissue, advanced magnetic navigation and infrared navigation techniques are used to assist in determining the tumor boundary.
(2) Preoperative PET-CT navigation sequence scan. Based on the difference in material metabolism between normal brain tissue and glioma tissue, combined with unit reconstruction techniques, to assist in intraoperative determination of tumor boundaries.
(3) Intraoperative electrophysiological detection techniques. The difference in electrical activity between neural tissue and tumor tissue is used to distinguish normal brain tissue from tumor tissue.
(4) Intraoperative fluorescence contrast technique. According to the difference of vascular abundance between tumor and normal tissues, intraoperative fluorescence contrast technique is used to achieve real-time intraoperative contrast and help determine the tumor boundary.
(5) Intraoperative ultrasound contrast technique. Using intraoperative ultrasound detection technology to help determine the extent of tumor resection in real time.
3.What are the specialties of postoperative radiotherapy?
Radiotherapy includes internal radiotherapy and external radiotherapy. Internal radiation therapy using local implantation of radioactive particles can make the local radiation dose achieve the effect of killing tumor cells. At the same time, the effective range of radiation released by the particles is controllable, which can well protect the vitality and function of the surrounding normal brain tissue. In addition, the radioactive particles have a specific half-life, so the radioactive contamination to the surrounding area is low. Based on these advantages, radioactive particle implantation endoradiotherapy is gradually being emphasized and clinically applied. We are one of the few units with professional certification in internal radiotherapy and have been carrying out internal radiotherapy for glioma treatment for many years with good results.
4.What is the unique feature of chemotherapy?
Malignant tumors are recognized as genetic diseases. Therefore, the molecular diagnosis obtained based on genetic testing is a good guide for postoperative chemotherapy. The quantitative and qualitative testing of tumor tissues at the molecular biology level can indirectly reflect the sensitivity of tumor cells to different chemotherapeutic drugs, thus realizing a “customized chemotherapy program for each patient”. This individualized chemotherapy based on molecular diagnosis is becoming the standard protocol in many glioma centers around the world.
5.What are the other leading therapeutic measures?
Malignant glioma treatment outcomes still need further improvement, so there are a number of clinical centers currently doing exploratory treatment studies. We are in the leading position in some aspects.
(1) Chemotherapy based on tumor stem cell theory. Tumor stem cells are considered to be the seed cells of tumors and the root cause of malignant tumor recurrence, so targeting tumor stem cells for treatment should lead to better outcomes.
(2) Injection of chemotherapeutic drugs or radioactive drugs into the tumor bed of the reservoir, changing systemic chemotherapy into local chemotherapy, which can significantly reduce the toxic side effects of chemotherapy drugs and improve the therapeutic effect.
(3) Cellular immunotherapy. Using autologous blood to screen immune cells in vitro, fusing individual tumor tissue antigens to activate immune cells in vitro, and then expanding them in vitro, and finally transfusing the sensitized immune cells back to the patient to realize immunotherapy with autologous cells, without allograft exclusion reaction.