The right thyroid nodule with calcification is a descriptive concept in ultrasound imaging, which mainly means that it may be benign or malignant. Benign calcification is considered to be annular calcification or large granular calcification, which is mainly caused by the formation of nodules in the thyroid gland and the deposition of some calcium salts, resulting in the formation of a certain amount of calcified foci. If the calcification associated with a thyroid nodule is fine or sand-like calcification, it is possible to suspect that the thyroid nodule is malignant, not only from the point of view of calcification, but also in combination with other indicators of ultrasound, such as the size of the nodule, the regularity of its shape, the presence of abundant blood flow signals, and the longitudinal to transverse ratio. A unilateral thyroid nodule with calcification cannot be completely classified as benign or malignant, but must be tested and diagnosed in conjunction with other indicators.