It is perfectly possible to have hyperthyroid symptoms without a thyroid nodule. The two are different concepts; hyperthyroidism refers to the functional aspect and nodules to the structural aspect. The symptoms of hyperthyroidism are due to increased synthesis of thyroxine by the thyroid gland, which leads to increased heart rate, increased differential pulse pressure, irritability, excessive drinking, excessive eating, and weight loss in the body. In clinical practice, hyperthyroidism is characterized by a diffuse enlargement of the thyroid gland, which may appear as a degree II or even III enlargement, and an increase in the synthesis and release of thyroxine from the thyroid gland. In cases of hyperthyroidism, medication is usually the first choice. In cases of poorly controlled medication or moderate or above primary hyperthyroidism, radioactive iodine therapy or surgery may be considered. In rare cases, the cause of hyperthyroidism may be due to the presence of a high-functioning adenoma, in which case complete removal of the high-functioning adenoma may provide relief or cure of the hyperthyroid symptoms, so it is perfectly possible to have hyperthyroid symptoms without a thyroid nodule.