For patients with chronic hepatitis B with childbearing requirements, if active hepatitis is present, they should try to receive treatment before conception, complete treatment 6 months before conception if possible, and use reliable contraception during treatment. For patients with chronic hepatitis B during pregnancy, they can be closely observed if the lesions are mild, or treated with tenofovir or telbivudine if they are severe. For patients with unintended pregnancy during antiviral period, termination of pregnancy is required if interferon is applied. If tenbivudine, tenofovir or lamivudine is applied, treatment can be continued; if entecavir or adefovir is applied, treatment should be continued by switching to tenofovir or tenbivudine. If the viral load is >2×106IU/mL in the middle and late pregnancy, treatment with tenofovir, tipifovir or lamivudine can be started in the 24th-28th weeks of pregnancy and discontinued 1-3 months after delivery, and breastfeeding can be done after discontinuation of the drug. Male patients applying interferon should stop the drug for at least 6 months before considering childbirth; patients applying nucleoside analogues can consider childbirth with adequate communication.