In normal people, the gallbladder wall thickens physiologically after eating meat, eggs and other high-protein or high-fat, fried food, because it is not easy to digest, and usually the thickening of the gallbladder wall will heal itself after 24 hours of eating. However, the thickening of gallbladder wall may also exist in pathological conditions such as gallbladder disease, accumulation of blood in the abdominal cavity and ascites, which usually cannot be self-healed and need to be treated accordingly. 1. gallbladder disease: gallstones, cholecystitis, etc., due to long-term stimulation of gallbladder stones, inflammatory exudative edema of the mucosal layer of gallbladder wall, resulting in significant thickening and thickening of the mucosal layer of gallbladder wall. The thickness of the gallbladder wall is >2mm, among which the mucosal layer is the most obvious. Generally, after drug anti-infection and surgical treatment, the gallbladder wall can be restored to normal, and the mucosal layer becomes smooth with a thickness of <2mm; 2. But after surgical treatment, the blood accumulation in the abdominal cavity will gradually disappear and the gallbladder wall will return to normal; 3, ascites: there are more causes of ascites, such as peritonitis, heart failure and other causes of hypoproteinemia, all of which will cause the gallbladder wall to be gross. When the original disease is healed and ascites disappears, the gallbladder wall roughness also returns to normal; 4, other: high fever, long-term bed-ridden fasting patients will also occur gallbladder wall roughness phenomenon, but the general symptoms are not obvious. After the fever is reduced and patients who are bedridden for a long time eat, the gross symptoms will gradually return to normal.