Principles of anti-compulsive drug therapy 1. Long-term principles Adequate anti-compulsive drug therapy should take at least 3-6 months, and some patients need longer to be considered the end of a course of treatment before the efficacy can be evaluated. You cannot take 1~2 months to assess the efficacy and decide to change the medication. Because the treatment of OCD is slow to take effect, unlike depression, depression can be evaluated after 2 months of taking medication and adjust the treatment plan, while OCD requires at least 3-6 months to do so. 2, the principle of adequate doses of anti-compulsive drug therapy are generally relatively large doses, sometimes even the highest dose stated in the instructions. This is because the efficacy of low-dose treatment is often very poor, so a larger dose should be applied. Of course, each patient’s situation is different, the specific dose of medication to determine the specific analysis, but in general, the dose of anti-compulsive treatment is on the high side. 3, maintenance time to be long The largest dose of anti-OCD drugs to achieve better results, it is generally recommended to maintain this dose for about 6 to 12 months, and then consider reducing the dose to maintain 2 to 3 years. First-line medication for OCD The preferred medications are: SSRI drugs (5-HT reuptake inhibitors): ① sertraline; ② fluoxetine; ③ paroxetine; ④ fluvoxamine. These four drugs are the first-line drugs, and clinical practice has proved that these four drugs are more effective. The pharmacological characteristics of these drugs are to increase the concentration of 5-HT in the central nervous system in the brain, thus acting as anti-compulsive, anti-depressant and anti-anxiety.