Pox generally refers to smallpox (a virulent infectious disease), smallpox virus mainly invades the body through the respiratory mucosa and is transmitted through droplet inhalation or direct contact. Smallpox virus has two strains of viruses with different virulence. Mainly severe toxemia symptoms (chills, high fever, fatigue, headache, limbs and back pain, body temperature rises sharply can appear convulsions, coma), the skin in batches of rashes, papules, herpes, pustules, and finally crusting, decab, leaving pox scars. Smallpox is a fierce and rapidly developing disease that kills up to 30% of the unimmunized population within 15 to 20 days of infection. Three to five days after the onset of the disease, a rash appears on the patient’s forehead, cheeks, wrists, arms, trunk and lower limbs. It starts as a red rash, then turns into a papule, and after 2-3 days the papule turns into a herpes, and later the herpes turns into a pustular rash. After 2 to 3 days, the pustular rash gradually dries up and forms a thick scab, and the scab begins to fall off after about 1 month, leaving a scar, commonly known as “pockmark”. Severe smallpox patients are often accompanied by complications, such as sepsis, osteomyelitis, encephalitis, meningitis, pneumonia, bronchitis, otitis media, laryngitis, blindness, miscarriage, etc., is the main cause of death from smallpox. This disease is mainly preventive, and smallpox vaccination (seed pox) is advocated.