Calcification is a normal physiological phenomenon that can be left behind by general inflammation or with age, so patients should not be anxious or afraid if they are diagnosed with calcified thyroid nodules, or calcification in other places such as the kidneys. Calcification of thyroid nodules is usually based on diffuse enlargement of the thyroid gland, through repeated proliferation and uneven recovery of follicular epithelial cells of the thyroid gland, forming hyperplastic nodules, further development of nodules, compression of inter-nodal blood vessels, making the nodules insufficient blood supply and deformation, necrosis, bleeding and other lesions. The hemorrhagic and necrotic tissues may gradually fibrosis, forming irregular scar, in which calcium salt deposition can occur, generally without particularly obvious clinical symptoms. However, we need to further examine whether the nodule calcification point is combined with cancer.