Menopause is the transitional stage of women from reproductive age to old age. With the decline of ovarian function, the lack of sex hormones will lead to a series of related clinical problems and diseases, which will seriously affect the health and quality of life of middle-aged and elderly women. The effects of menopause include 3 stages: Stage 1: Menstrual disorders, irritability, night sweats, memory loss, anxiety and depression, etc. If left untreated, menstrual disorders may trigger endometrial precancerous lesions; Stage 2: Menopause shows signs of ovarian depletion starting from the exterior, manifesting as skin atrophy, degeneration and aging of internal and external genitalia and breasts, etc.; Stage 3: After the age of 60 The third stage: after the age of 60, internal changes occur, which manifest as bone loss leading to osteoporosis, fractures, abnormal blood sugar and lipid metabolism leading to cardiovascular diseases, Alzheimer’s disease, etc., and can lead to death in severe cases. This shows that menopausal hazards include menstrual disorders and menopausal symptoms in the near future, but also include long-term hazards such as osteoporosis and cardiovascular diseases, and even dementia. Therefore, good prevention and health care in different stages of menopause is of great significance to improve menopausal symptoms, reduce the occurrence of chronic metabolic diseases and improve the quality of life of middle-aged and elderly women. Hormone supplementation therapy is used to treat the immediate and long-term harm caused by estrogen deficiency at the root.