The treatment of acute exacerbation of chronic bronchitis includes the following points. The first is to control infection, antibacterial drug treatment can choose quinolones, macrolides, and β-lactams these drugs. Then is to suppress cough and expectoration, you can apply compound licorice combination, aminoglutethimide hydrochloride and so on. Another is to calm asthma, and those who have shortness of breath can add antispasmodic and antiasthmatic drugs. Treatment in remission includes quitting smoking, avoiding inhalation of harmful gases and other harmful particles, strengthening physical fitness and preventing colds, which is also one of the main elements in the prevention and treatment of chronic bronchitis. Recurrent respiratory infections can be treated with a trial of immunomodulators or Chinese medicine or herbal medicine.