Healthy men who undergo genetic testing can know if they are at high risk for testicular cancer, and such a new study is getting closer to us. Testicular cancer is a cancer that originates in the testicles. The testes are two glands located below the male scrotum and penis that produce sperm and testosterone. Although the testes contain a variety of different types of cells, each of which can cause one or more cancers, the vast majority of testicular cancers originate in the germ cells. This type of cancer is known as testicular germ cell tumors (TGCT). Compared to other cancers, testicular cancer is not as common. In fact, a man’s lifetime risk of developing testicular cancer is 1 in 263, or less than 0.5%. It is also one of the most curable cancers, with a risk of death from testicular cancer of about 1 in 5,000. However, testicular cancer is the most common cancer in men between the ages of 15 and 34. The American Cancer Society estimates that in 2017, there will be approximately 8,850 newly diagnosed cases of testicular cancer and 410 testicular cancer deaths in the United States. In addition, it is becoming increasingly apparent that the genetic risk for testicular cancer is not caused by a single faulty gene, but by several “single word” changes in DNA, or “risk loci.