Thyroid nodules are nodules or lumps in the parenchyma of the thyroid gland, most of which are non-cancerous and do not cause disease. The cause of the disease is not very clear. The cause of thyroid nodules is the result of a combination of factors, such as abnormal iodine, impaired hormone synthesis, and so on. These include some common underlying causes and triggers. Basic causes: 1. Iodine deficiency can lead to thyroid nodules. Both normal adults and growing children need sufficient daily intake of iodine to meet the thyroid hormone thyroid hormone is the hormone secreted by the thyroid gland. White needle-like crystals. Odorless. Tasteless. Deteriorates when exposed to light. Melting point 231-233℃ (decomposition). Insoluble in water and common organic solvents such as ethanol. Soluble in ethanol containing inorganic acid or base, also soluble in hydroxide base and carbonate base solution. Adding sodium nitrite to its acidic ethanol solution, it turns yellow when heated, and then turns pink when an excess of ammonia is added. Chemical essence: thyroxine, which is T4, is tetraiodothyronine. The need for synthesis is the basis for the fact that iodized table salt can prevent goiter and nodules. However, in some iodine deficient areas, iodine intake is insufficient and the thyroid gland cannot synthesize enough thyroid hormone, which feedback causes the pituitary gland to secrete TSH (thyroid stimulating hormone) Thyroid stimulating hormone (TSH) is a hormone secreted by the adeno-pituitary gland, whose main function is to control and regulate the activity of the thyroid gland.) In excess, TSH levels in the blood rise, stimulating hypertrophy of the thyroid gland and the formation of thyroid nodules. 2: High iodine also leads to thyroid nodules, a rare cause of thyroid nodules. Thyroid nodules caused by this cause can be sporadic or endemic. There are some areas where the water quality contains too much iodine, and residents of that area drink high iodine water for a long time, which can lead to a decrease in the function of thyroid peroxidase, affecting the process of tyrosine iodination. 3: The process of organicization of elemental iodine is blocked, and the thyroid gland shows compensatory enlargement and nodule formation. The use of iodine-containing drugs can lead to thyroid nodules. Familial hereditary diseases can have genetic defects, usually autosomal recessive, and are generally caused by hereditary defects in thyroid synthase, resulting in defects in thyroid hormone synthesis, or lack of hydrolytic enzymes, which can lead to thyroid hormone synthesis but not normal release, leading to thyroid hyperplasia and nodule formation. Triggering factors: 1. In some individuals who are prone to thyroid nodules, stimulated by triggering factors, can make the thyroid gland hyperplastic goiter is actually a non-toxic goiter, also known as simple goiter, which is an enlargement of the thyroid gland caused by insufficient secretion of thyroxine, prompting increased secretion of TSH. It even produces thyroid nodules, such as during puberty, pregnancy, lactation, cold, severe infection and trauma, and obvious mental stimulation, which can induce goiter or nodule formation due to the body’s increased need for thyroid hormones. 2, there are some substances that can easily lead to thyroid nodules can also induce the production of thyroid nodules. For example, foods such as cabbage, soybeans, white radish, cassava, millet, foods high in calcium and water can induce thyroid nodules. There are medications that can also be triggering factors, such as sulfonamides, thioureas, botrytisine, colchicine, lithium, para-aminosalicylic acid, etc. Sulfur-containing organic substances (which include thiocyanides, disulfides, etc.), flavonoids, and benzodicarboxylic acid esters can cause thyroid nodule formation. Such substances can inhibit iodine ion synthesis into the thyroid gland, thus causing changes in thyroid morphology.