Thyroid cancer is one of the most harmful diseases among all thyroid disorders, and there is no ideal treatment yet. Patients with enlarged thyroid nodules should consider the possibility of thyroid cancer if they have the following conditions: 1. sudden and rapid enlargement and hardening of the lump; 2. people receiving radiation treatment for other diseases in the neck, especially adolescents; 3. hard, uneven surface, fixed, poorly defined borders and poor mobility of thyroid nodules; 4. enlarged lymph nodes in the neck or metastasis elsewhere; 5. hoarseness, difficulty in breathing and swallowing Long-term watery diarrhea, flushing of cheeks, and other endocrine tumors; 7. Calcification on thyroid ultrasound with thin images and blurred borders; 8. “hot” nodules; 9. Active cells are confirmed by puncture cytology or histology. If the malignancy of the nodule cannot be determined after various methods of examination, regular follow-up observation and repeated examination are required, and it should never be left unattended. If necessary, surgical exploration is performed, and rapid frozen pathology is performed during surgery.