Hiccups, belching, reduced number of exhausts and bowel movements and abdominal distension in patients with advanced hepatocellular carcinoma may most commonly be caused by peritoneal effusion and fundic esophageal varices, which may further cause slowing of gastrointestinal motility, decreased digestive function and edema of stomach wall and intestinal canal, all of which may lead to decreased digestive function and belching. Patients should actively consider checking the liver function to see if there is a decrease in albumin, the albumin in the blood below 25g/L is mostly considered edema and peritoneal effusion and hypoproteinemia, intravenous infusion of plasma and albumin for symptomatic support treatment, when the patient’s albumin rises above 30g/L, diuretic drugs, such as hydrochlorothiazide and spironolactone diuretic treatment, peritoneal effusion and Gastrointestinal wall edema will recover slowly. Some patients with advanced hepatocellular carcinoma are in a better financial situation and may consider taking targeted drugs such as sorafenib and lenvatinib for active treatment.