With high temperatures and rain in summer and fall, sometimes a small trauma can easily lead to infection. This leads to an increase in infectious diseases in the summer and fall. One of the most serious infectious diseases is infective endocarditis. Recently, the cardiovascular surgery and infection departments of the hospital have jointly treated five such patients, all of whom sought medical attention for unexplained fever. The director of cardiovascular surgery at the General Hospital told reporters that infective endocarditis is often caused by septic bacteria and mainly invades the valves of the heart, which may cause ulceration, perforation, rupture and redundancy of the valves and tendons. These superfluous organisms may be shed, and the shed superfluous organisms become bacterial emboli that can lead to embolism and migrating abscesses, which are very troublesome. The bacteria that cause bacterial endocarditis are often highly pathogenic, with Staphylococcus aureus, Streptococcus hemolyticus, Streptococcus pneumoniae, S. influenzae, S. pyogenes, and E. coli being the most common. It is often secondary to infections in other parts of the body, which in turn may lead to infections in other parts of the body and is more aggressive. Acute infective endocarditis usually occurs in the normal heart, with sepsis as the main clinical manifestation, rapid onset and progression, with toxic symptoms such as high fever, chills, and malaise. The heart may develop a high-pitched heart murmur, which rapidly progresses to acute heart failure. The skin may have bruising and purpura-like hemorrhagic damage. It is easily overlooked by the primary infectious disease. Examination of the heart should not be neglected in individuals with a recent history of infectious disease or infectious surgery. Prevention: Due to advances in cardiac surgery and the widespread use of antibiotics, atypical or specific types of infectious endocarditis are increasing, such as after prosthetic valve replacement, hemodialysis, or corrective surgery for precardiac disease, all of which increase the chance of endocardial infection, and patients with postoperative fever should be alerted. Patients with heart valve disease or cardiovascular malformations and artificial valves should enhance their physical fitness, pay attention to hygiene, remove infected lesions in a timely manner, and apply antibiotics prophylactically when doing dental and upper respiratory tract surgery, surgery of the low gastrointestinal tract, gallbladder, and genitourinary tract. Laboratory tests: increased leukocytes, positive blood cultures, echocardiographic findings of heart valve changes. Principles of treatment The prognosis of this disease depends on the early or late treatment, the ability of antibiotics to control the primary bacteria, the degree of damage to the heart valves, and the patient’s resistance. Treatment should also be based on this principle. 1. Early and adequate use of effective antimicrobial agents for a sufficiently long period of time, with intravenous administration preferred. Gong Lu, director of the Infection Department at the General Hospital of Medical University, recommends a dosing cycle of 4—8 weeks. Many times it is also necessary to co-administer the drug. 2, in the course of antibiotic treatment if there is heart failure or the original heart failure aggravated, the emergence of new murmur or murmur multivariate, embolism, etc., are signs that the infection can not be controlled, need to consider changing antibiotics. 3.Strengthen the supportive therapy, after improving the general condition, it is advisable to use high protein, high calorie, high vitamin, easy to digest diet, and for those with cardiac insufficiency, low salt diet should be given. 4. Strive for early surgery. The patient in this case had a strong virulence of the causative bacteria, which directly invaded the aortic valve and caused aortic valve insufficiency, resulting in acute heart failure. After clear diagnosis, the doctor performed emergency surgery under extracorporeal circulation to replace the aortic valve and clean up the infected lesion at the same time, and the patient was successfully treated; one of the patients had congenital heart disease combined with infective endocarditis and disseminated pulmonary infection, and after adequate antibacterial treatment, surgery was successfully performed four weeks later. Special reminder Patients with unexplained fever for more than one week should go to a regular general hospital for detailed examination, paying attention to cardiac auscultation changes, skin bleeding spots and embolic phenomena. It often needs to be differentiated from influenza, acute arthritis, acute septic meningitis, and acute pyelonephritis. Patients who delay too long may have progressive deterioration and often lose the opportunity for surgery.