The differences between coronary artery disease and GERD are as follows: 1. pain location: typical coronary artery disease is mainly in the left chest, while GERD is in the midline of the sternum; 2. pain duration: coronary artery disease is not more than ten minutes, while GERD can be more than 0.5-1 hour; 3. underlying disease: coronary artery disease has more underlying cardiovascular disease, while GERD has more history of chronic gastrointestinal disease; 4. relief 4, relief: coronary heart disease can be relieved by nitroglycerin, while GERD requires acid-suppressing drugs.