Gastroesophageal reflux can be treated with domperidone, the main function of which is to promote the restoration of gastrointestinal power and help empty the food in the stomach. After treatment with domperidone, the food in the stomach can be discharged as soon as possible to avoid excessive secretion of gastric acid, thus inhibiting the appearance of acid reflux. Domperidone not only coordinates the smooth muscle function of the stomach and duodenum, but also enhances the tone of the lower esophageal sphincter, thus avoiding the reflux of food from the stomach into the esophagus and the violation of the esophageal mucosa. Patients with gastroesophageal reflux should be treated with domperidone in combination with drugs such as omeprazole and colloidal bismuth, which can inhibit gastric acid secretion and promote the repair of the gastroesophageal mucosa to achieve the role of rapid treatment of the disease.