Gastroesophageal reflux disease belongs to the common diseases of the digestive system and is divided into the following three types: 1) erosive esophagitis; 2) non-erosive gastroesophageal reflux disease; and 3) Barrett’s esophagus. Among them, erosive esophagitis and Barrett’s esophagus are relatively heavy, especially Barrett’s esophagus is the most serious. Gastroesophageal reflux disease mostly manifests as heartburn, noisy, acid reflux, and burning pain behind the sternum, and is mostly treated with omeprazole, rabeprazole, aluminum magnesium carbonate tablets, aluminum magnesium plus, gastric bismuth magnesium, mosapride, and domperidone, along with traditional Chinese medicine. Chinese medicine believes that GERD is mostly caused by heat in liver, gallbladder and stomach, choose clear heat and cold drugs, such as Huanglian, Scutellaria baicalensis, cuttlebone, bamboo rhizome, substitution ochre, half a summer and other drugs for treatment, the efficacy is long-lasting, sure, worth promoting. The specific medication should be combined with the clinical situation and guided by the doctor’s face-to-face consultation.