A 1992 statistic found that women’s chances of developing depression increased with age, with the rate of major depression in the general population being 7%, compared to 11-23% in perimenopausal women. Some women may be mildly depressed until age 40, but may develop major depression after age 40. This depression may also be accompanied by severe anxiety, restlessness and even impulsivity leading to suicidal ideation and behavior. Congenital physical defects, combined with physical and psychological stress, make women vulnerable to depression. Congenital constitution refers to the special structure of the brain cells of an individual that is more prone to anxiety and depression-related symptoms. Physiological stress is manifested by a decrease in the production of sex hormones. Animal studies have shown that E2 increases 5-HT transmission and inhibits NE reabsorption, promotes the effects of 5-HT1a and inhibits the effects of 5-HT2a, and even plays the role of MAOI. A, which can act as an anti-anxiety hormone, and P is even thought to be anti-epileptic; T, DHEA, and DHEAS all have a positive regulatory effect on mood and libido. Psychological stress can also induce depression and anxiety. Aging can cause a number of diseases as well as functional decline, and this functional decline may cause a decline in self-identity. Retirement may cause a sense of worthlessness, and at this time, the patient enters a window of absence where he or she begins to feel lonely, bored, empty, and worthless.