Pain caused by rheumatic diseases can be treated with drugs for anti-inflammatory and pain relief. Rheumatic diseases refer to a large group of diseases caused by genetic, infectious, endocrine, immune and other factors that lead to bone, joint, muscle and peripheral soft tissue lesions, of which the common diseases include rheumatoid arthritis, systemic lupus erythematosus, gouty arthritis, polymyositis and ankylosing spondylitis. For rheumatic diseases caused by joint and surrounding tissue pain, swelling and joint dysfunction and other symptoms, can be targeted to anti-inflammatory, pain management, commonly used drugs, including etoricoxib, celecoxib and naproxen and other non-steroidal anti-inflammatory drugs and prednisone, methylprednisolone and other steroids and anti-inflammatory drugs. Drugs should be used under the guidance of a physician, and it is recommended that patients with rheumatic diseases go to the rheumatology and immunology departments of regular hospitals and follow the doctor’s instructions for standardized treatment.