Indications for donor insemination are: 1. irreversible azoospermia, severe oligospermia, weak spermia and teratospermia. 2. Failure of vasectomy recanalization. 3, Ejaculation disorders. 4.The male partner and/or family has serious hereditary diseases that are not suitable for fertility. 5.Mother and child blood type incompatibility cannot get a surviving newborn. In indications 1, 2 and 3, except for irreversible azoospermia, patients requiring donor insemination must understand that it is also possible to obtain self-referred offspring through intracytoplasmic single sperm microinjection technique. If the patient still insists on waiving his or her right to conception by intracytoplasmic single sperm microinjection, he or she must sign an informed consent before using donor insemination for conception. Donor insemination is possible in the presence of severe oligospermia, hypospermia and teratozoospermia, but it is important to know that in such cases, the use of intracytoplasmic single sperm microinjection may also result in offspring who are related by blood, or the offspring may not be infected with hepatitis B. If the couple still insists on renouncing the use of the husband’s sperm, donor insemination can be used to assist conception after signing the relevant informed consent form.