For newly diagnosed glioblastoma, maximum safe resection of the tumor is preferred, and molecular characterization of the glioma is clarified by molecular testing of tissue specimens for the presence of IDH1/2 mutations and MGMT promoter methylation. Temozolomide synchronized radiotherapy is recommended for patients under 70 years old and in good physical condition. The details are as follows: Adjuvant therapy is initiated 4-6 weeks after surgery, including two phases of temozolomide synchronous radiotherapy and adjuvant chemotherapy Synchronous phase Radiotherapy is administered by fractionated external irradiation, currently using conformal intensity-modulated radiotherapy (radiotherapy from Monday to Friday, with Saturdays and Sundays off, for a total of 42 days). Temozolomide was started on the first day of radiotherapy (75mg/m2 orally 1/day) and was taken without interruption for 42 days. Adjuvant chemotherapy phase After 4 weeks of rest at the end of radiotherapy, the first cycle of adjuvant chemotherapy is started at 150mg/m2 orally 1/day for 5 days, with 23 days of rest. If the patient tolerates it well, the second cycle can be given at the beginning of the second cycle 200mg/m2 orally 1/day for 5 days with 23 days of rest. A total of six cycles of adjuvant therapy were given. Blood tests will be performed weekly during the synchronization period; during the adjuvant period, blood tests will be performed on day 22. Depending on the results, antihematologic treatment or temozolomide dose adjustment will be made as appropriate. How do I take Temozolomide? Take it on an empty stomach and do not take it again after vomiting. The details are as follows: take an antiemetic such as ondansetron or toltesetron tablets; take temozolomide (swallowed whole) after half an hour; eat after another hour. Patients who are older and in a worse state of life, reduce the intensity of treatment according to the actual situation.