Throughout history, many women have sighed and lamented about the ease of passing years. And exhaustive methods to retain the youthfulness and beauty of the flower. The most important thing is that the roots of the tree are as deep as those of the tree, so that the leaves can flourish. The physiological essence of youth is the good function of the ovaries. The physiological age is often inconsistent with the age of the ovaries —— the so-called 20-year-old body, 40-year-old ovaries. If a woman under the age of 40 has ovarian function like perimenopause, it is “premature ovarian failure”. Guangdong Family Planning Specialist Hospital Women’s Department Zhang Biyun daily life, we often see the following example: Xiaozhi girl 25 years old, three years after graduation has been engaged in sales work in foreign companies, rising performance, good pay, leadership appreciation, the scenery is unlimited, enviable. However, she herself often feels irregular in her work and rest on business trips across the country recently, and she is under a lot of pressure at work and has insomnia and dreams. The previous regular “aunt” is also becoming more frequent, and the amount is less. When I sit down to think about something, I get a cold sweat. When I went to the hospital, the doctor said “premature ovarian failure”. I am really anxious! What are the ovaries? The most important internal reproductive organ of women is located in the pelvis, one on each side, the size of a red date. The function of the ovaries includes reproductive and endocrine functions, i.e. breeding follicles, producing eggs and secreting female hormones. The normal functioning of the ovaries is of great importance to women’s reproductive health and overall health. Is premature ovarian failure rare? According to statistics, the worldwide prevalence of premature ovarian failure is about 1:10,000 in women <20 years old, 1:1,000 in women <30 years old, and 1:100 in women <40 years old, so there is one in every 100 women between the ages of 30 and 40 years old! A domestic study showed that the clinical incidence of premature ovarian failure is 3.2%, which supports the view that the incidence of POF is on the rise. Therefore, premature ovarian failure is not so far away from us, but so close! So, how do you know if you have premature ovarian failure? (a) From clinical symptoms: 1. Abnormal uterine bleeding, i.e.: prolonged menstrual period (more than 1 week of unclean menstruation), reduced menstrual flow (less than 2-3 sanitary napkins per day), frequent menstruation (less than 21 days of menstruation), or scanty menstruation (more than 35 days of menstruation still coming), or even amenorrhea (more than 3 months to 6 months of future menstruation), etc. Hot flashes, night sweats, lack of mental concentration, agitation and irritability or depression, and inability to control oneself. Autonomic disorders, such as dizziness, insomnia, tinnitus, palpitations, etc. aggravate anxiety and inhibitions. 2. Somatic and psychosomatic symptoms: such as hot flashes, night sweats, lack of mental concentration, emotional agitation, irritability or depression, uncontrollable, etc. Affects the work and life of women. Autonomic dysregulation, such as dizziness, insomnia, tinnitus and palpitations, aggravate anxiety and inhibitions. 3. Genitourinary tract symptoms and sexual function effects Long-term low estrogen can lead to atrophy of the genitourinary tract, pain and difficulty in sexual intercourse. This can lead to recurrent vaginal infections and decreased libido, i.e., difficulty in sexual intercourse. (b) From experimental tests: Premature ovarian failure is defined as an elevated level of gonadotropin (FSH) (FSH>40IU/mL) and a decreased level of estrogen (E2) (E2<< span="">73.2pmol/L) in peripheral blood before the age of 40 years in the second early follicular phase (i.e., within the second to fifth days of menstruation). If FSH>20IU/ml, the possibility of premature ovarian failure is not excluded; if FSH>10IU, it suggests a decline in ovarian function. In addition, LH/FSH>2~3.6 during the early follicular phase (i.e. within the 2nd-5th days of menstruation) suggests poor ovarian reserve function, while FSH may be within the normal range at this time. It is an early sign of poor ovarian function and would suggest a poor response to superovulation (COH) in patients undergoing assisted reproduction. AMH is produced by follicular granulosa cells in the early stages of follicular development and peaks in early adulthood (20-25 years of age), then gradually decreases until it reaches undetectable levels within 5 years before menopause. Therefore, AMH can be significantly different in women of the same age, thus allowing the prediction of the remaining length of the female reproductive life span through AMH. AMH detection is not restricted to different periods of menstruation, and its superiority in predicting ovarian function and measuring ovarian age is gaining popularity in the field of female reproduction. Young women, value your youth and cherish your ovaries! Observe your discomfort carefully and get checked as early as possible to prevent any problems before they occur! This article is published with the permission of Dr. Biyun Zhang.