OBJECTIVE: To investigate the surgical treatment of neonatal intestinal atresia and the factors affecting the prognosis. METHODS: To summarize the clinical data of 44 cases of new ~_JL Jll idiopathic lock, 3 cases of duodenal atresia, 16 cases of jejunal atresia, and 25 cases of ileal atresia. Pathological types, 5 cases of septal type, 37 cases of blind end type, and 2 cases of multisegmental type. Results: 38 cases survived, with a postoperative survival rate of 86.4%. Postoperative follow-up ranged from 1 to 10 years. The outcome was satisfactory. There were 3 cases of postoperative death. CONCLUSION: Surgery is the only means of treatment for this disease, and the surgical approach should be selected according to the site and type of atresia. The efficacy of this disease is influenced by several factors. Prenatal ultrasonography is beneficial for prognosis.