(I) Oral medication Indications: ① People with symptomatic signs due to hemangioma compression or occupancy, including those who have not yet obvious manifestations at the time of consultation, but can be predicted to be the lesions in the early proliferative stage, which may affect the function and appearance of the children in the future. (If important parts or organs are involved, such as subglottic or tracheal hemangioma with asthma and dyspnea; periocular hemangioma combined with strabismus, myopia, amblyopia, and protruding eyeballs, etc.; huge hemangioma in parotid area is expected to be left behind after regression of the parotid area with fatty fibrous tissue, and the plastic surgery may injure the facial nerve); hemangiomas in the nose, lips, joints, and so on. (iii) Multiple hemangiomas of the whole body. Giant segmental hemangioma. ⑤PHACE syndrome. For some lesions which are small, with slow growth or even stagnation, and expected to have little effect on appearance and function, oral drug treatment can be considered, and observation is recommended to wait for the natural regression of hemangiomas. For those who are eager to be treated, careful explanation is needed to avoid over-treatment, which may cause adverse consequences to the children instead. (II) Injection 1, local injection of tretinoin: Indications: hemangioma whose tumor is higher than 3mm above the skin surface, with subcutaneous mass. 10-15 days/times, usually about 3 times of injection. If gastrointestinal discomfort or other symptoms occur during treatment, taking vitamin B1, vitamin C and calcium tablets at the same time can effectively reduce or prevent the occurrence of side effects. Steroid injections have been successfully used in the treatment of periorbital hemangiomas, soft tissue atrophy is more common, but temporary, when the hemangioma spreads backward into the orbit, the systemic steroid treatment should be used (a study of 70 children with a total of 74 hemangiomas, intra-lesional steroid injections, the result was that 58% of the children with a tumor reduction of 75% or more, 22% of the children with a 50-70% reduction, 12% of the children with a 25-50% reduction, the results of the tumor reduction of 25-70%, the result of the tumor reduction. The result was that 58% of the children had more than 75% reduction of tumor, 22% had 50-70% reduction, 12% had 25-50% reduction, and 8% had less than 25% improvement, with an average follow-up of 14 months, and no tumor growth after treatment). Corticosteroid hormone therapy for hemangiomas can be administered orally or by local injection into the tumor cavity, with an efficiency rate of up to 90%. However, the side effects of hormone therapy are obvious, including signs such as full moon face, buffalo back and centripetal obesity. 2.Local injection of anhydrous ethanol: Ethanol is a kind of very invasive sclerosing agent, its dehydration and stripping effect makes hemoglobin denatured and destroys the endothelial cells of blood vessels, which rapidly causes necrosis and thrombosis of lesion tissues, this invasive effect is the mechanism of ethanol treatment of vascular malformations, for normal tissues, such as nerves, muscles or connective tissues, it is necessary to pay attention to avoid that ethanol enters into the arteries of its blood supply and leads to the necrosis of these normal tissues. After anhydrous ethanol injection, the tumor cavity produces aseptic inflammation due to the stimulation of the chemical nature of the drug, and the local swelling and pain reaction can be obvious, especially in the treatment of parapharyngeal and buccal tumors, the respiratory machine swallowing can be affected due to the local edema, and the hormone should be given orally to reduce the edema reaction, and the injection site should not be too shallow, or there is a risk of causing the skin to ulcerate and hemorrhage occurs, and as far as possible when injecting and for a few minutes after injecting When injecting and a few minutes after injecting, pressurize to block the blood flow in the lesion area, so as to prolong the stay time of anhydrous ethanol in the tumor cavity and enhance the therapeutic effect. Monthly review of liver function, renal function, and blood and urine routine, if there is any abnormality, it should be suspended, and then continue the treatment after it returns to normal. 3.Interferon Interferon is the second line of drugs for the treatment of severe giant hemangioma, interferon-α2a is a kind of powerful and well tolerated de cytokine, liver function and blood monitoring should be carried out during the treatment period, and there is a risk of thyroid function and neurological complications in long-term treatment. Interferon inhibits angiogenesis by inhibiting vascular smooth muscle cells and capillary endothelial cells. In one case study, 20 cases of hemangiomas in Wayside were resistant to corticosteroids, and after an average of 8 months of treatment, 18 cases were more than 50% calf. Anti-tumor drug pingyangmycin local injection for the treatment of hemangioma is a new therapy emerging in recent years, its efficiency can be up to 90% or more, but it can cause patients with fever, interstitial pneumonia and other complications, and in severe cases can lead to anaphylactic shock. Interferon is a new treatment for vascular road in recent years, the clinical effect is satisfactory, but due to cause digestion, hematopoietic, neurological adverse reactions and limit its application in the clinic. 4.Sodium cod liver oil sodium cod liver oil sodium local injection can induce endovascular endocarditis and other pathophysiological changes, the effective rate of treatment of hemangioma reaches more than 85%, but the pain is obvious when injecting, and there are occasional allergic reactions, and the local scar may be formed in the late stage. At present, there are many kinds of non-surgical and local injection methods applied in the treatment of pediatric hemangioma, and all methods have certain efficacy, but also have certain side effects and limitations. (C) Surgical treatment of hemangioma 1. Surgical treatment: for the limited parts. The growth is fast. For hemangioma which is limited in location, growing fast, not effective in other treatments, not involving joints and important organs, etc. (At present, surgery is still the most effective treatment for hemangioma. (At present, surgery is still the main means to treat hemangioma and vascular malformation, but some hemangiomas are not easy to be completely removed by surgery due to the special location, or the appearance and function may be seriously affected by surgical removal. In addition, many children and their families are still afraid of surgery). 2.Laser treatment If the hemangioma is in the thin flat stage or for the early performance of local capillary expansion, it is advocated to use laser coagulation of hemangioma blood vessels for early intervention treatment. In order to minimize the expansion of the tumor, ulceration, bleeding and obstruction of important organs. ND: YAG laser, with a wavelength of 1064 nm, penetrates very deep tissue (about 2-8 mm) PDL, with a penetration depth of 0.6-1.2 mm at 585 nm, is thus limited to relatively superficial lesions effectively, but its safety and specificity are better. Early studies have shown that PDL accelerates regression of proliferative lesions as well as slows or stops hemangioma proliferation, and PDL is most effective in eliminating hemangiomatous lesions that are in the patchy stage prior to the pre-proliferative stage. It has been reported that treatment is most effective when the hemangioma bulges 3 mm or less, and treatment is recommended in the first week of life. In one study of 33 hemangiomas in 24 patients (aged 2 weeks to 6 months), superficial lesions were reduced by 93.9% after 4.1 treatments. Seven lesions with a thickness of 4 mm or more were reduced by 83.7% after 7 treatments. Whether early treatment prevents the proliferative phase and, in particular, whether it can affect deeper lesions that cannot be reached by PDL light. There are reports stating that deeper layers proliferate despite superficial partial regression during PDL treatment. The opposite situation also exists, where only the deep part responds to steroid treatment and the superficial part is unaffected. 3.Combination therapy Hemangioma is a common benign tumor in maxillofacial area, the incidence rate accounts for 60-80% of the total number of hemangiomas in the whole body, most of them are present at birth, the principle of treatment is to destroy the pathological vascular tissues, and the clinical treatment is mainly based on surgery, and the tumor is huge in scope, affecting the face, oral cavity and important organs, such as pharynx, cheeks, lips, face, etc., the surgery can not be resected at one time and there is a lot of bleeding from the incision, therefore, it can only be taken as a comprehensive treatment. Combined interferon or simple systemic prednisone therapy, hemangioma embolization, tumor volume reduction and dermal component excision, and PDL laser treatment of superficial may be used.