Lupus nephritis is one of the most common secondary glomerulonephritis, and the word “wolf” in the name makes many people inexplicably afraid of this disease. So, what is lupus nephritis all about? Why do you get lupus nephritis? What are the signs of lupus nephritis? How to treat it? Can lupus patients get pregnant, and so on. These are the questions that lupus patients and their (their) family members are concerned about. We will answer these questions one by one. Today we will start with the following questions: 1) What is lupus nephritis all about? Lupus nephritis is one of the important organ damages of SLE. SLE is an autoimmune disease that often involves multiple organ systems throughout the body, producing a variety of different clinical manifestations. Lupus nephritis is the most common manifestation, and its severity directly affects the prognosis of SLE. 2) Why do you get lupus nephritis? The cause of the development of lupus nephritis is not clear. However, in general, it is the result of the interaction between genetic and environmental factors. On the one hand, there is a genetic defect in immune regulation, and on the other hand, the stimulation of certain acquired factors contribute to the development of the disease. These acquired factors include food, drugs (hydrazidiazide, procainamide, methyldopa, isoniazid, penicillin, D-penicillamine, aminosalicylic acid, etc.), ultraviolet light, microorganisms (bacteria, viruses, parasites), as well as smoking and dust. The incidence of lupus nephritis is significantly higher in women of childbearing age than in other populations, indicating that estrogen also has an influence on the development of the disease 3) Is lupus nephritis contagious? As mentioned earlier, lupus is an autoimmune disease, which is the result of abnormal immune regulation in the body, not caused by a certain pathogen, and therefore is not contagious. 4) Is lupus nephritis hereditary? Lupus is related to heredity. The incidence of lupus in close relatives of lupus patients is 5-12%, and the incidence in identical twins can reach 23-69%. However, it does not mean that if parents have lupus nephritis, their children will definitely get sick as well, but only that the possibility of starting the disease is greater than others. As you can see, SLE is a common disease caused by abnormalities in the immune regulation of the body, and the kidneys are the most commonly affected organ. Lupus nephritis is not contagious, and although its occurrence is associated with genetic factors, most patients do not show hereditary predisposition.