As I told you before, wound infection is the main cause of health threat to diabetic foot patients. Once the infection is not controlled, it is easy to trigger an inflammatory reaction, and a large amount of toxins will be absorbed by the body and sepsis will occur, with really serious consequences. Let’s take a look at the characteristics of different degrees of infection and then develop a targeted treatment plan. No infection: no systemic or local symptoms or infection Infection: presence of 2 or more of the following symptoms: local swelling or hard nodules, erythema extending >0.5 cm (around the wound), local pressure or pain, local fever, purulent discharge. Mild infection Infection involving only skin or subcutaneous tissue, any erythema extending <2 mm (around the trauma), no systemic symptoms or signs of infection, other causes of inflammatory skin reaction should be excluded (e.g. trauma, gout, acute Charcot arthropathy, fracture, thrombosis, venous stasis). Moderate infection Infection involving tissues deeper than the skin and subcutaneous tissues (e.g. bone, joint, tendon, muscle), any erythema extending >2 mm (around the trauma), no systemic symptoms or signs of infection. Severe infection Any foot infection with systemic inflammatory response syndrome with 2 or more of the following symptoms present: temperature >38°C or <36°C, heart rate >90 beats/min, respiratory rate >20 breaths/min or partial pressure of carbon dioxide <32 mmHg (4.3 kPa), white blood cell count <4 x 109/L or >12 x 109/L, or immature white blood cells >10%.