Growth hormone (GH) is a protein hormone produced by the anterior pituitary growth hormone cells. GH is necessary for normal growth and plays an important role in the function of the heart, kidneys, skin, internal organs, bones, muscles and gonads, as well as in the metabolism of sugar, fat and protein in the human body. Growth hormone deficiency can cause a series of abnormalities such as short stature, osteoporosis, muscle dysplasia, susceptibility to cardiovascular diseases, sexual dysplasia and aging. Recombinant human growth hormone (rhGH) is a biological agent made by recombinant gene technology, which was produced in the 1980s and has been used for nearly three decades to treat pituitary GHD as well as non-GHD short stature, such as congenital ovarian hypoplasia (Turner syndrome), small for gestational age children, Prader-Willi syndrome, chronic renal failure, and premature aging. Chronic renal failure and adjuvant therapy for precocious puberty, etc. The U.S. Food and Drug Administration (FDA), the most stringent agency in the world, approved the following indications for growth hormone: 1985 Growth hormone deficiency (GHD) in children. 1993 Chronic renal insufficiency before kidney transplantation. 1996 HIV infection-related failure syndrome. 1996 Turner syndrome short stature. 1997 GHD replacement therapy in adults. 2000 Prader-Willi syndrome. 2001 Smaller than gestational age (SGA). 2003 Idiopathic short stature (ISS). 2003 Short bowel syndrome. 2006 SHOX gene deficiency in children without GHD. In recent years, rhGH has also been found to have more prominent efficacy in anti-aging and weight loss treatment, and a Dutch study suggests that rhGH has a beneficial effect on mental development.