Osteoporosis is a systemic bone metabolic disease that increases the brittleness of bones due to the reduction of bone mass and the deterioration of bone quality, which can easily cause fractures. It is an “invisible killer” because osteoporosis is asymptomatic in the early stages, but gradually invades the bones, resulting in pain, bone deformation, fractures, etc. In severe cases, it even causes physical disability, which affects the quality of life and may bring a series of complications that endanger life. From the female point of view, in general, women start to lose bone mass from the age of 30-40, and the bone mass lost during their lifetime accounts for 40-50% of the peak, while men only account for 20-30%, and within 5 years after menopause, bone mass loss reaches 15%, after which the rate of rapid decline in bone mass begins to slow down. Therefore, women in the perimenopause is also the best time to prevent osteoporosis. A healthy lifestyle, moderate physical activity, proper sun exposure, and a balanced diet with calcium vitamin D and moderate protein intake are all good preventive methods. It is worth mentioning that for women who have bad habits such as smoking and drinking, sitting indoors a lot, not being physically active, or having a thin body, fair skin, flat chest and menopause before the age of 45 are the high prevalence of osteoporosis. In addition to basic preventive measures, appropriate hormone replacement therapy under the guidance of doctors is necessary and safe. However, the so-called female hormone supplements on the market without strict approval should be used with caution, because the nature and dosage of the hormones contained in them are ambiguous, and improper use may cause unnecessary damage to the organism.