Selective 5-hydroxytryptamine reuptake inhibitors ( SSRIs, paroxetine), tricyclic antidepressants (TCA), selective 5-hydroxytryptamine and noradrenaline reuptake inhibitors (SNRI, venlafaxine), selective 5-hydroxytryptamine reuptake activators (SSRA, tianeptine), dopamine and noradrenaline reuptake inhibitors (NDRI, bupropion), norepinephrine adrenergic and specific 5-hydroxytryptaminergic antidepressants (NaSSA, mirtazapine) are all antidepressants that also have anxiolytic effects. Selective 5-hydroxytryptamine reuptake inhibitors (SSRIs) are the first-line therapeutic agents for the treatment of depressive and anxiety disorders. Five drugs are currently in common use: paroxetine, sertraline, citalopram, fluoxetine, fluvoxamine Tricyclic antidepressants (TCAs) are not suitable for the treatment of patients with cardiovascular disease with depressive and anxiety disorders due to the damage that tricyclic antidepressants have on the heart, increasing the risk of death in cardiac patients. Increased QT dispersion and decreased rhythm variability increase ventricular fibrillation and sudden cardiac death. To date, several studies have shown that tricyclic antidepressants reduce rhythm variability and increase QT dispersion, whereas SSRI antidepressants do not reduce rhythm variability. Benzodiazepines (BDZ) are anxiolytics For patients with anxiety disorders or depressive disorders with anxiety symptoms should apply benzodiazepines BDZ along with SSRIs and other drugs to control anxiety symptoms as soon as possible, wait for SSRIs and other drugs to take effect, and then slowly withdraw BDZ. Selective 5-hydroxytryptamine and norepinephrine reuptake inhibitors (SNRI, venlafaxine), the selective 5-hydroxytryptamine reuptake activator (SSRA, tianeptine), dopamine and norepinephrine reuptake inhibitor (NDRI, bupropion), norepinephrine and specific 5-hydroxytryptaminergic antidepressant (NaSSA, mirtazapine) can be used according to the condition. In addition to benzodiazepines, which can rapidly relieve anxiety symptoms, the dosing time is relatively short. Other antidepressants and anxiolytics are generally slow to take effect and require patients to be patient, and once they take effect, the medication duration is relatively long, requiring at least 1 year of continuous use. Even if the medication is taken for 1 year, many patients will relapse again after stopping it, and some patients need to take the medication for a long time.