Dry syndrome is an autoimmune disease (diffuse connective tissue disease) that affects the majority of women. About 90% of patients with dry syndrome are women (repeat), usually of middle age or older. The most typical pathological changes of dry syndrome can reduce the secretion of exocrine glands. This leads to some dryness symptoms in the eyes, mouth and gastrointestinal tract of the body, which is the origin of the name of this disease. Dry mouth is the most common manifestation of dryness, mainly because the disease can lead to the reduction of oral saliva secretion, and the mouth lacks the moistening effect of these saliva. In severe cases, it is necessary to have water and liquid food to eat when eating. With reduced saliva secretion, the mouth is dry and lacks the action of lysozyme in the saliva, which makes it extremely easy for bacteria to grow, as well as frequent oral mucosal ulcers and flaky tooth loss and rampant tooth loss. The tear glands of the eyes secrete less tears, and the conjunctiva lacks the wetness of tears, which leads to dryness and stinging symptoms. The lack of the flushing effect of tears on the conjunctiva can lead to bacteria staying and gathering for too long, triggering conjunctivitis and other conjunctival diseases. The mucous membrane of the digestive tract is also involved in patients with dry syndrome, and secretions are reduced compared to normal. Gastrointestinal symptoms such as anorexia and digestive disorders can occur. Dry syndrome can also cause a purpuric rash to appear on the skin of the patient, and when this symptom occurs, the skin does not fade when pressed. This is mainly due to the active period of the disease, the body’s immune system activates its function, hyperglobulinemia, etc., which releases some vasodilating substances, resulting in increased vascular permeability and leakage of red blood cells and other components of the blood from the vessel walls, causing bleeding from the tiny blood vessels under the skin. Patients may also have joint pain, and joint pain is one of the common symptoms of dry syndrome patients. The disease can lead to aseptic inflammation of the synovial membrane of the joints, which can be painful and cause problems such as joint effusion. Dry syndrome, like other autoimmune diseases, is characterized by systemic multisystem involvement. Patients who are diagnosed with dry syndrome should be treated aggressively. If the disease is serious, it will cause serious damage to the organs in the body. Such as interstitial lung fibrosis, primary biliary cirrhosis and renal tubular acidosis.