Acne is also known as closed pimples and acne vulgaris. After puberty, the level of androgens in the body, especially testosterone, rises rapidly, promoting the development of sebaceous glands and producing large amounts of sebum. At the same time, abnormal keratinization of the sebaceous ducts of hair follicles causes blockage of the ducts, resulting in obstruction of sebum discharge. Endocrine dysfunction, increased secretion of androgens or relatively high secretion of androgens stimulates sebaceous gland hypertrophy and hyperplasia, and increased secretion of sebum, mainly due to increased level of androgen secretion, which promotes active and increased sebum secretion. Endocrine imbalance is an internal factor that induces acne and is the main factor for its appearance. Excessive secretion of hormones in the body stimulates the sebaceous glands to secrete sebum and produce more sebum. The greasy sebum mixed with the old keratin that is normally shed will easily block the pores and cause acne because the sebum cannot be discharged normally. In addition, closed hair follicles provide a beneficial environment for the rapid reproduction of P. acnes bacteria, and the chemicals they produce can lead to inflammation of the skin around the hair follicles, which in turn can lead to acne. A woman’s premenstrual period is mainly influenced by hormones. During the premenstrual period or during menstruation, small pimples will appear on the face, and disappear after the period. Acne is a chronic skin disease, and acne is a type of acne. After puberty, gonadal hormones increase and acne begins to appear, which is a sign of acne. Pimples, papules, and pustules are all acne. Acne mostly occurs in adolescents. Excessive secretion of skin fat and clogged pores during adolescence make it easy for acne to form, and after puberty, acne usually heals naturally.